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J Aller Cl Imm-Pract:孕妇孕前体重指数和妊娠期体重增加与子女特应性皮炎之间的关系

2018-11-12 xing.T MedSci原创

由此可见,在这项研究中,GWG增加与子女特应性皮炎风险增加有关。这支持了现有证据,即产前暴露有助于特应性疾病的发生发展。

孕妇体重状况可能会促进儿童特应性疾病的发生发展。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,该研究的目的是评估孕妇孕前体重指数(BMI)和妊娠期体重增加(GWG)与儿童特应性皮炎风险之间的关系。

在一项针对美国儿童的前瞻性队列研究-GUTS研究中,研究人员通过通过问卷调查了孕妇孕前BMI和GWG。母亲们报告了GUTS参与者在1997年或1999年,也即GUTS参与者介于10-17岁之间时,是否曾被临床医生诊断为特应性皮炎。研究人员使用多变量Logistic回归来估计BMI和GWG与后代特应性皮炎之间的关联(表现为比值比(OR)与95%置信区间)。

在13269名GUTS参与者中,2058名(16%)参与者患有儿童特应性皮炎。母亲孕前BMI较高与子代特应性皮炎无关(趋势P=0.48)。相比之下,GWG与特应性皮炎风险增加相关(趋势p=0.005)。相较于孕妇体重了25-34磅的子女,孕妇体重了增加了35-44磅(OR为1.11,0.98-1.26)和≥45磅(OR为1.23,1.05-1.43)的子女发生特应性皮炎的风险增加。在孕前BMI>25的孕妇中这些关联似乎更强(GWG 35-44磅:OR为1.20,0.84-1.69;GWG≥45磅:OR为1.57,1.07-2.31),但BMI和GWG之间的统计学相互作用并不显著。

由此可见,在这项研究中,GWG增加与子女特应性皮炎风险增加有关。这支持了现有证据,即产前暴露有助于特应性疾病的发生发展。

原始出处:

Aaron M. Drucker,et al.Association between maternal pre-pregnancy body mass index, gestational weight gain, and offspring atopic dermatitis: a prospective cohort study. J Aller Cl Imm-Pract. 2018.https://doi.org/10.1016/j.jaip.2018.10.044

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    2019-08-21 szhvet
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    2018-11-14 膀胱癌
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    2018-11-13 王秀

    学习了,涨知识了!

    0

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    2018-11-13 飛歌

    厉害了我的妹

    0

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