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Alzheimer's & Dementia:华山医院团队发布,教育降低我国老年人群痴呆症发病率

2020-09-06 haibei MedSci原创

华山医院团队通过对比相隔20年进行的上海老年痴呆症和阿尔茨海默病流行病学调查(SESD)和上海老龄化研究(SAS)的数据,研究老年痴呆症患病率和发病率的变化。

估算和预测痴呆症的疾病负担,对公共卫生、社会政策、老龄人口痴呆护理的资源配置都有影响。据《2016年世界阿尔茨海默报告》估计,全球痴呆症患者人数为4700万,预计到2050年,这一数字将增加到1.31亿以上。

关于痴呆症患者人数不断增加的公认预测可能会受到新出现的证据的挑战,这些证据表明,在过去40年里,痴呆症的流行率和发病率稳定或下降。这些证据来自基于人口的队列研究,对医疗记录或保健管理数据库的分析,统计建模,以及系统性审查和荟萃分析。其中大多数研究是过去几年在西欧和北美的高收入国家进行的。只有少数研究是在这些地区以外进行的,并报告了不同的趋势。

在全球7.81亿成人文盲中,75%以上生活在南亚、西亚和撒哈拉以南非洲,那里的平均预期寿命增长最快。这些证据可以用来预测痴呆症的负担,特别是在占世界人口85%的中低收入国家。

痴呆症的流行和发病率的长期趋势在中国人群中很少被研究。上海痴呆和阿尔茨海默病流行病学调查(SESD)和上海老龄化研究(SAS)是分别于1987年和2010年在上海市中心同一地区建立的基于地理定义的人群研究。这些研究为我们提供了一个独特的机会,通过这两个相隔20年进行的队列研究来探索痴呆症流行和发病的长期趋势,尤其是低教育背景人群的趋势。研究人员推测,低教育程度的老年人痴呆症的患病率和发病率有上升趋势。

最近,华山医院团队就在Alzheimer's & Dementia杂志发文,通过对比相隔20年进行的上海老年痴呆症和阿尔茨海默病流行病学调查(SESD)和上海老龄化研究(SAS)的数据,研究老年痴呆症患病率和发病率的变化。

研究人员发现,SAS总参与者中痴呆症的患病率和发病率均高于SESD(患病率:6.44% vs 2.30%,P < 001;年发病率:2.58% vs 1.33%,P < .001)

在受教育年限≤6年的参与者中,SAS的痴呆患病率高于SESD(患病率:6.39% vs 3.07%,P < .001);SAS的痴呆年发病率是SESD的两倍(3.63% vs 1.80%,P = .019)。

因此,研究人员观察到中国老年人,尤其是低学历老年人的痴呆症患病率和发病率呈上升趋势。痴呆症患者数量的急剧上升,很可能发生在低学历人群中。

 

原始出处:

Ding Ding et al. Prevalence and incidence of dementia in an older Chinese population over two decades: The role of education. Alzheimer's & Dementia (2020). DOI: https://doi.org/10.1002/alz.12159

 

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  4. 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    2020-09-18 ms1000000375036815

    不错

    0

  5. 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  6. 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    2020-09-07 Psycho.Dr Du

    所以想要防痴呆,还是得多读书#老年痴呆症#

    0

  7. 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    2020-09-06 146465bem06暂无昵称

    华山棒棒

    0

  8. 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    2020-09-06 1381abdab4m

    #教育#能减少#老年性痴呆#的发生,那么,国外基本普及了高等教育,为什么仍然是老年性痴呆高发?其实更多的原因,可能并不是教育,而是经济发展,老人间的交流更多,压力下降,#广场舞#增加了,这些因素可能是减少老年性痴呆的关键! 本研究之所以得出教育因素,是典型的偏倚!虽然是#华山医院#的研究成果,但是我们也不能一味地相信,要辩证地眼光看待这个研究。

    0

  9. 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本研究之所以得出教育因素,是典型的偏倚!虽然是<a href='/topic/show?id=75d23590149' target=_blank style='color:#2F92EE;'>#华山医院#</a>的研究成果,但是我们也不能一味地相信,要辩证地眼光看待这个研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57599, encryptionId=5e625e59918, topicName=教育), TopicDto(id=80164, encryptionId=bdb78016436, topicName=老年性痴呆), TopicDto(id=49139, encryptionId=963a4913969, topicName=广场舞), TopicDto(id=35901, encryptionId=75d23590149, topicName=华山医院)], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/13/dc2daedd2690b46dd6d059a772da6ba3.jpg, createdBy=f0f41699279, createdName=1381abdab4m, createdTime=Sun Sep 06 12:43:04 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048656, encodeId=67ed104865689, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Sep 06 15:15:25 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883095, encodeId=e98888309509, content=这个研究成果好,大样本,结果更可信, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=872a5416098, createdName=ms8000001383773561, createdTime=Sun Sep 06 13:29:10 CST 2020, time=2020-09-06, status=1, ipAttribution=)]
    2020-09-06 junJUN

    老年人痴呆何药可用??

    0

  10. 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本研究之所以得出教育因素,是典型的偏倚!虽然是<a href='/topic/show?id=75d23590149' target=_blank style='color:#2F92EE;'>#华山医院#</a>的研究成果,但是我们也不能一味地相信,要辩证地眼光看待这个研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57599, encryptionId=5e625e59918, topicName=教育), TopicDto(id=80164, encryptionId=bdb78016436, topicName=老年性痴呆), TopicDto(id=49139, encryptionId=963a4913969, topicName=广场舞), TopicDto(id=35901, encryptionId=75d23590149, topicName=华山医院)], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/13/dc2daedd2690b46dd6d059a772da6ba3.jpg, createdBy=f0f41699279, createdName=1381abdab4m, createdTime=Sun Sep 06 12:43:04 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048656, encodeId=67ed104865689, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Sep 06 15:15:25 CST 2020, time=2020-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883095, encodeId=e98888309509, content=这个研究成果好,大样本,结果更可信, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=872a5416098, createdName=ms8000001383773561, createdTime=Sun Sep 06 13:29:10 CST 2020, time=2020-09-06, status=1, ipAttribution=)]
    2020-09-06 ms8000001383773561

    这个研究成果好,大样本,结果更可信

    0

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