Biological Psychiatry：残酷的现实-你的收入和社会地位在影响着孩子的脑发育

2021-03-05 MedSci原创 MedSci原创

SES通过应激敏感的皮质醇分泌形成儿童杏仁核-前额叶环路，其中杏仁中央内侧核与处理负面情绪的腹内侧和背外侧PFC的功能协调作用最为显著。该研究发现为了解社会经济差异如何影响儿童情绪发育的神经生物学病因

社会经济差异通过应激激素反应影响儿童的杏仁核-前额叶回路背景家庭的社会经济地位(SES)几乎可以影响儿童生活的方方面面，包括现在和未来的成就以及健康。低SES对儿童情绪发展的潜在不利影响被认为是由压力等近端因素造成的。然而，潜在的神经生物学机制仍然难以捉摸。北师大秦绍正团队结合神经心理、生理心理、静息态和情感认知任务下功能性磁共振成像（fMRI）技术方法，揭示了社会经济地位通过压力激素皮质醇介导儿童大脑情感环路的作用途径。研究成果在Biological Psychiatry杂志。

该研究观察SES对6~12岁儿童综合皮质醇分泌的影响及其对情绪相关脑系统和连通性的调节作用。研究1调查239名儿童SES与皮质醇分泌的关系。在研究2中，通过对50名儿童进行静息状态和任务相关的功能磁共振成像，研究了SES是如何通过皮质醇分泌影响儿童杏仁核-前额叶功能组织的。

他们发现低SES儿童皮质醇分泌减少，介导杏仁核与内侧和背外侧前额叶皮质(PFC)的内在功能联系。关键的是，这些儿童还通过杏仁中央内侧核与内侧PFC之间更高的内在连接，表现出更高的任务诱发的vmPFC活性。在处理负面情绪时，他们还表现出杏仁中央内侧核与DLPFC的更高的功能耦合度。

SES通过压力激素分泌介导CMA/BLA-mPFC/dlPFC自发功能连接

SES通过压力激素分泌和静息态CMA-MPFC自发功能连接，从而介导负性情感任务下vmPFC的更高激活水平

SES通过压力激素介导负性情感加工中CMA-dlPFC功能耦合增强

总的来说，SES通过应激敏感的皮质醇分泌形成儿童杏仁核-前额叶环路，其中杏仁中央内侧核与处理负面情绪的腹内侧和背外侧PFC的功能协调作用最为显著。该研究发现为了解社会经济差异如何影响儿童情绪发育的神经生物学病因提供了重要的见解。

原文出处：B T T A , C C B Y , D Y Z A , et al. Socioeconomic disparities affect children's amygdala-prefrontal circuitry via stress hormone response[J]. Biological Psychiatry, 2021.

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2021-06-21 diushouji

#Psychiatry#

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2022-01-07 yankaienglish

#脑发育#

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2022-01-10 12498ebem31暂无昵称

#Biol#

66 0
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createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Jan 07 18:03:03 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767831, encodeId=50411e67831a7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Jan 10 10:03:03 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919220, encodeId=2dd61919220dd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jun 15 09:03:03 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965511, encodeId=29b696551143, content=经济条件越好，下一代得到的教育越优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri May 14 12:16:56 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027570, encodeId=b377202e5702c, content=<a href='/topic/show?id=caa7e397190' target=_blank style='color:#2F92EE;'>#社会地位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73971, encryptionId=caa7e397190, topicName=社会地位)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Nov 23 12:03:03 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347531, encodeId=127c134e53167, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617046, encodeId=4138161e046ba, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945662, encodeId=213e94566215, content=<a href='/topic/show?id=53131042020c' target=_blank style='color:#2F92EE;'>#残酷的现实#</a> 为自己、为孩子，努力奋斗吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104202, encryptionId=53131042020c, topicName=残酷的现实)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Mar 05 10:20:16 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
2021-06-15 sunylz

#Bio#

62 0
[GetPortalCommentsPageByObjectIdResponse(id=1792211, encodeId=e0071e9221178, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jun 21 17:03:03 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950558, encodeId=87ef1950558e6, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Jan 07 18:03:03 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767831, encodeId=50411e67831a7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Jan 10 10:03:03 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919220, encodeId=2dd61919220dd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jun 15 09:03:03 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965511, encodeId=29b696551143, content=经济条件越好，下一代得到的教育越优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri May 14 12:16:56 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027570, encodeId=b377202e5702c, content=<a href='/topic/show?id=caa7e397190' target=_blank style='color:#2F92EE;'>#社会地位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73971, encryptionId=caa7e397190, topicName=社会地位)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Nov 23 12:03:03 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347531, encodeId=127c134e53167, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617046, encodeId=4138161e046ba, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945662, encodeId=213e94566215, content=<a href='/topic/show?id=53131042020c' target=_blank style='color:#2F92EE;'>#残酷的现实#</a> 为自己、为孩子，努力奋斗吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104202, encryptionId=53131042020c, topicName=残酷的现实)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Mar 05 10:20:16 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
2021-05-14 威天

经济条件越好，下一代得到的教育越优秀

79 0
[GetPortalCommentsPageByObjectIdResponse(id=1792211, encodeId=e0071e9221178, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jun 21 17:03:03 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950558, encodeId=87ef1950558e6, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Jan 07 18:03:03 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767831, encodeId=50411e67831a7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Jan 10 10:03:03 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919220, encodeId=2dd61919220dd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jun 15 09:03:03 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965511, encodeId=29b696551143, content=经济条件越好，下一代得到的教育越优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri May 14 12:16:56 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027570, encodeId=b377202e5702c, content=<a href='/topic/show?id=caa7e397190' target=_blank style='color:#2F92EE;'>#社会地位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73971, encryptionId=caa7e397190, topicName=社会地位)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Nov 23 12:03:03 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347531, encodeId=127c134e53167, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617046, encodeId=4138161e046ba, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945662, encodeId=213e94566215, content=<a href='/topic/show?id=53131042020c' target=_blank style='color:#2F92EE;'>#残酷的现实#</a> 为自己、为孩子，努力奋斗吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104202, encryptionId=53131042020c, topicName=残酷的现实)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Mar 05 10:20:16 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
2021-11-23 marongnuan

#社会地位#

69 0
[GetPortalCommentsPageByObjectIdResponse(id=1792211, encodeId=e0071e9221178, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jun 21 17:03:03 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950558, encodeId=87ef1950558e6, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jun 15 09:03:03 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965511, encodeId=29b696551143, content=经济条件越好，下一代得到的教育越优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri May 14 12:16:56 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027570, encodeId=b377202e5702c, content=<a href='/topic/show?id=caa7e397190' target=_blank style='color:#2F92EE;'>#社会地位#</a>, beContent=null, objectType=article, channel=null, 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target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), 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2021-03-07 neurowu

#发育#

67 0
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level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73971, encryptionId=caa7e397190, topicName=社会地位)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Nov 23 12:03:03 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347531, encodeId=127c134e53167, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617046, encodeId=4138161e046ba, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945662, encodeId=213e94566215, content=<a href='/topic/show?id=53131042020c' target=_blank style='color:#2F92EE;'>#残酷的现实#</a> 为自己、为孩子，努力奋斗吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104202, encryptionId=53131042020c, topicName=残酷的现实)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Mar 05 10:20:16 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
2021-03-07 ms705947299214030

#社会#

57 0
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createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Jan 07 18:03:03 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767831, encodeId=50411e67831a7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Jan 10 10:03:03 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919220, encodeId=2dd61919220dd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jun 15 09:03:03 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965511, encodeId=29b696551143, content=经济条件越好，下一代得到的教育越优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri May 14 12:16:56 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027570, encodeId=b377202e5702c, content=<a href='/topic/show?id=caa7e397190' target=_blank style='color:#2F92EE;'>#社会地位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73971, encryptionId=caa7e397190, topicName=社会地位)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Tue Nov 23 12:03:03 CST 2021, time=2021-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347531, encodeId=127c134e53167, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617046, encodeId=4138161e046ba, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945662, encodeId=213e94566215, content=<a href='/topic/show?id=53131042020c' target=_blank style='color:#2F92EE;'>#残酷的现实#</a> 为自己、为孩子，努力奋斗吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104202, encryptionId=53131042020c, topicName=残酷的现实)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Mar 05 10:20:16 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
2021-03-05 14701415m17暂无昵称

谢谢

106 0
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createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Jan 07 18:03:03 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767831, encodeId=50411e67831a7, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Jan 10 10:03:03 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919220, encodeId=2dd61919220dd, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jun 15 09:03:03 CST 2021, time=2021-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=965511, encodeId=29b696551143, content=经济条件越好，下一代得到的教育越优秀, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210514/93eea3544b5040b1b858429af5ec9094/53ca7982022a4c16a9c37b2e5ee96f51.jpg, createdBy=bf315465790, createdName=威天, createdTime=Fri May 14 12:16:56 CST 2021, time=2021-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027570, encodeId=b377202e5702c, content=<a href='/topic/show?id=caa7e397190' target=_blank style='color:#2F92EE;'>#社会地位#</a>, beContent=null, objectType=article, channel=null, 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target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Sun Mar 07 01:03:03 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945679, encodeId=32b09456e9b6, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210105/2c5d1fff2f364aa1a6a15dce4f80b863/ba6fa61b9a0b471993f38425efccec11.jpg, createdBy=a9085183839, createdName=14701415m17暂无昵称, createdTime=Fri Mar 05 11:28:02 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945662, encodeId=213e94566215, content=<a href='/topic/show?id=53131042020c' target=_blank style='color:#2F92EE;'>#残酷的现实#</a> 为自己、为孩子，努力奋斗吧！, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104202, encryptionId=53131042020c, topicName=残酷的现实)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Mar 05 10:20:16 CST 2021, time=2021-03-05, status=1, ipAttribution=)]
2021-03-05 Jessica

#残酷的现实# 为自己、为孩子，努力奋斗吧！

99 0

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