Sci Rep：癌抗原-125对肺腺癌伴脑转移患者的预后价值

2018-04-07 xiangting MedSci原创

对于肺腺癌伴脑转移患者，验证后的预后列线图（KPS、吸烟、EGFR-20和Ca125）能够更准确地预测患者的1年和2年生存率。

这项研究使用随机生存森林，旨在评估血清标志物对肺腺癌伴脑转移(BM)患者的预后价值，并试图将其整合到预后模型中。

2010年至2015年期间，从两个医疗中心寻找病人。除了Cox比例风险回归之外，使用随机生存森林（RSF）从A组（n = 142）建立预后模型。在A组的RSF中，首先排除最小深度大于深度阈值或具有阴性变量重要性（VIMP）的因子。随后，使用C指数和AIC准则（AIC）来寻找具有较高预后能力和较低过拟合可能性的模型。

这些RSF模型与Cox，对改良RPA和肺部GPA指数进行了验证和比较，尤其是B组（CAMS，n = 53）。研究数据表明，KSE125模型（KPS，吸烟，EGFR-20（外显子18,19和21）和Ca125）在生存预测中是最佳的，并且在内部和外部验证中表现良好。

总之，对于肺腺癌伴脑转移患者，验证后的预后列线图（KPS、吸烟、EGFR-20和Ca125）能够更准确地预测患者的1年和2年生存率。

原始出处：

Hao Wang, et al. Prognostic value of cancer antigen -125 for lung adenocarcinoma patients with brain metastasis: A random survival forest prognostic model. Sci Rep. 04 April 2018.

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2018-07-24 肉我只吃一口

#癌抗原-125#

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2018-05-27 智慧医人

#脑转移患者#

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2018-04-09 paperyu

#预后价值#

61 0
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2018-04-09 xiaoyeshuang

#抗原#

61 0
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2018-04-08 13718711b3m

学习了.获益匪浅.感谢分享

93 0
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2018-04-07 1ddf0692m34(暂无匿称)

学习了.长知识

83 0
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2018-04-07 sunfeifeiyang

阅

97 0

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