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Thyroid:COVID-19患者甲状腺功能分析

2020-07-01 MedSci原创 MedSci原创

血清TSH和TT3的变化可能是COVID-19患者病程的重要体现。

自2019年12月由严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)引起的2019冠状病毒疾病(COVID-19)爆发以来,它已影响六大洲的200多个国家和地区。目前,尚不清楚COVID-19是否对甲状腺功能有影响。近日,甲状腺疾病领域权威杂志Thyroid上发表了一篇研究文章,这项研究的目的是评估COVID-19患者的甲状腺功能。

研究人员对50例经实验室检查确诊的无甲状腺疾病病史且在COVID-19感染过程中及恢复后均进行了甲状腺功能检查的患者进行了回顾性分析,评估了受试者的临床表现、实验室检查结果和胸部CT扫描结果。他们于2020年1月至2020年3月之间被送往浙江大学医学院附属第一医院收治。健康参与者在相同的时间段内接受了常规体检,同时期的严重程度相似的非COVID-19肺炎患者被纳入研究作为对照组。研究人员分析并比较了COVID-19患者与对照组之间的甲状腺激素和甲状腺刺激激素(TSH)水平。

56%(28/50)的COVID-19患者的TSH低于正常范围。COVID-19患者的TSH水平和血清总三碘甲状腺素(TT3)水平显著低于健康对照组和非COVID-19肺炎患者。COVID-19越严重,TSH和TT3水平越低,且具有统计学意义(p<0.001)。TSH和TT3水平的降低程度与疾病的严重程度呈正相关。COVID-19患者的总甲状腺素(TT4)水平与对照组无显著差异。所有患者均未接受甲状腺激素替代治疗。恢复后,在COVID-19患者与对照者之间,TSH、TT3、TT4、游离三碘甲状腺氨酸(FT3)和游离甲状腺素(FT4)水平没有显著差异。

由此可见,血清TSH和TT3的变化可能是COVID-19患者病程的重要体现。

原始出处:

Min Chen,et al.Thyroid function analysis in 50 patients with COVID-19: a retrospective study.Thyroid.2020.https://www.liebertpub.com/doi/10.1089/thy.2020.0363

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