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J Stroke:中国人群家族史与脑卒中危险因子的相关性

2017-08-09 shaosai MedSci原创

目前,尚缺乏对亚洲人群脑卒中家族史(FHS)和脑卒中危险因子关系的大型研究。本研究旨在系统的评价在50万中国成人中脑卒中家族史(FHS)和脑卒中危险因子的相关性,并发表在J Stroke上。

目前,尚缺乏对亚洲人群脑卒中家族史(FHS)和脑卒中危险因子关系的大型研究。本研究旨在系统的评价在50万中国成人中脑卒中家族史(FHS)和脑卒中危险因子的相关性,并发表在J Stroke上。

FHS信息的采集由病史采集获得。随访中位时间为7.16年,脑卒中发病后结束随访,然后直接进入中国Kadoorie Biobank系统。联合考克斯比例风险模型进行多变量回归分析以及交互作用分析利用似然比检验方法。

与无FHS的患者相比,有FHS的患者发生脑卒中的危险比(HR)为1.50.随着直系亲属发生脑卒中的数量增加,HRs增加。在兄弟姐妹和父母发生脑卒中的HRs分别为1.57 (95% CI: 1.50-1.66) and 1.49 (95% CI: 1.45-1.54)。在父母有脑卒中病史中,子孙间的相关性也是相似的。另外,在FHS和健康-危险行为(吸烟和酗酒)间有显着的交互作用。

本研究表明,在中国人群中,FHS是脑卒中的独立危险因子。当直系亲属患有脑卒中,个人发生脑卒中的危险程度越高。对于健康人群,尤其是有FHS的人群,对健康-危险行为的管理是非常重要的。

原始出处:

Tian T, Jin G, Yu C , et al,Family History and Stroke Risk in China: Evidence from a Large Cohort Study. Stroke. 2017.DOI: 10.5853/jos.2016.01270

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    2017-08-10 flysky120

    谢谢,学习一下知识了

    0

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    2017-08-10 龙胆草

    学习谢谢分享

    0

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    2017-08-09 1dd8c52fm63(暂无匿称)

    学习学习,了解了解

    0

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    2017-08-09 哈哈869

    学习

    0

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