Nature Cell Biology：休眠的毛囊干细胞抑制皮肤鳞癌的发生

2014-01-02 佚名环球医学资讯

来自美国加州大学洛杉矶分校伊莱和伊迪特-布罗德再生医学与干细胞中心的研究人员发现，某些成体干细胞在它们的休眠阶段能够抑制它们启动皮肤癌产生的机制。这一发现可能被用来开发出更好的癌症预防策略。相关研究结果于2013年12月15日在线发表在Nature Cell Biology期刊上。【原文下载】毛囊干细胞是能够产生毛囊的组织特异性成体干细胞，也是皮肤鳞状细胞癌(cut

来自美国加州大学洛杉矶分校伊莱和伊迪特-布罗德再生医学与干细胞中心的研究人员发现，某些成体干细胞在它们的休眠阶段能够抑制它们启动皮肤癌产生的机制。这一发现可能被用来开发出更好的癌症预防策略。相关研究结果于2013年12月15日在线发表在Nature Cell Biology期刊上。【原文下载】

毛囊干细胞是能够产生毛囊的组织特异性成体干细胞，也是皮肤鳞状细胞癌(cutaneous squamous cell carcinoma)产生的细胞起源，其中皮肤鳞状细胞癌是一种常见性的皮肤癌。这些干细胞周期性地处于激活阶段(在此期间，它们能够生长)和静止阶段(在此期间，它们保持休眠状态)。

利用模式小鼠，White和Lowry将已知的致癌基因导入毛囊干细胞之中，结果发现在它们的休眠阶段，这些干细胞不能启动皮肤癌产生。一旦它们处于激活阶段，它们开始产生这种癌症。

White说，“我们发现这种通过成体干细胞休眠而产生的肿瘤抑制作用受到PTEN的调节，其中基因PTEN在调节细胞对信号转导途径作出反应中发挥着重要作用。因此，对毛囊干细胞而言，干细胞休眠是一种新的肿瘤抑制形式，若要这种抑制发挥作用，PTEN必需存在。”

理解干细胞休眠抑制癌症产生可能能够有助为某些患者提供预防性策略，比如特别容易患上皮肤鳞状细胞癌的器官移植受者，还比如那些服用药物维罗非尼(vemurafenib)治疗黑色素瘤(另一种类型的皮肤癌)的患者。

原文出处：

White AC1, Khuu JK1, Dang CY1, Hu J1, Tran KV1, Liu A1, Gomez S1, Zhang Z2, Yi R2, Scumpia P3, Grigorian M1, Lowry WE4.Stem cell quiescence acts as a tumour suppressor in squamous tumours.Nat Cell Biol. 2014 Jan;16(1):99-107. doi: 10.1038/ncb2889. 【原文下载】

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2014-09-29 zhaozhouchifen

#Cell#

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2014-02-12 sunylz

#Bio#

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2014-01-17 yese

#休眠#

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createdName=1696533704_45270456, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=)]
2014-11-01 维他命

#CEL#

51 0
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createdName=1696533704_45270456, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=)]
2014-11-20 liye789132251

#Nat#

58 0
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level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Tue Sep 02 01:59:00 CST 2014, time=2014-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389111, encodeId=66ef1389111ab, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, topicName=毛囊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441132, encodeId=69ce14411323f, content=<a 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createdName=1696533704_45270456, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=)]
2014-09-02 12498ebem31暂无昵称

#Biol#

63 0
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createdName=1696533704_45270456, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=)]
2014-01-03 1249857fm32暂无昵称

#毛囊#

84 0
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createdName=1696533704_45270456, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=)]
2014-01-03 ms7474195563676018

#毛囊干细胞#

68 0
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level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Tue Sep 02 01:59:00 CST 2014, time=2014-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389111, encodeId=66ef1389111ab, content=<a href='/topic/show?id=c130636834c' target=_blank style='color:#2F92EE;'>#毛囊#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63683, encryptionId=c130636834c, topicName=毛囊)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441132, encodeId=69ce14411323f, content=<a href='/topic/show?id=5d9963686b4' target=_blank style='color:#2F92EE;'>#毛囊干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63686, encryptionId=5d9963686b4, topicName=毛囊干细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bcbd4793927, createdName=ms7474195563676018, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484596, encodeId=65fa14845965d, content=<a href='/topic/show?id=3502102944e7' target=_blank style='color:#2F92EE;'>#鳞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102944, encryptionId=3502102944e7, topicName=鳞癌)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20171006/a73877485ccdf6add82293e671bebe21.jpg, createdBy=745a7977375, createdName=1696533704_45270456, createdTime=Fri Jan 03 23:59:00 CST 2014, time=2014-01-03, status=1, ipAttribution=)]
2014-01-03 1696533704_45270456

#鳞癌#

66 0

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