Metabolism：肥胖和2型糖尿病住院患者的孟德尔随机化研究

2022-02-04 从医路漫漫 MedSci原创

2019冠状病毒病(COVID-19)大流行是由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染引起的。SARS- cov -2的毒性不像SARS，大量患者无症状或症状较轻

背景：2019冠状病毒病(COVID-19)大流行是由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染引起的。SARS- cov -2的毒性不像SARS，大量患者无症状或症状较轻。大量感染者(约80%)为无症状或轻度症状，使病毒传播更加难以控制。另一方面，肥胖和2型糖尿病(T2D)等风险因素增加了COVID-19相关住院的严重程度和比例。调查COVID-19相关住院的危险因素，有必要开发有效的预防性治疗方法。特别是，Stefan等人综述的大型研究表明，肥胖，尤其是体重指数(BMI)≥35 kg/m2的患者，是严重COVID-19的一个强大的独立决定因素。据报道，在住院的COVID-19患者中，肥胖和2型糖尿病(T2D)均高度富集。由于肥胖与T2D密切相关，因此研究肥胖和T2D是否与COVID-19住院独立相关是很重要的。

目的：采用孟德尔随机化(MR)方法，探讨肥胖与T2D在COVID-19住院患者中的因果关系。研究设计与方法:本研究采用两样本MR分析方法，将GIANT联盟在全基因组关联研究(GW AS)中确定的肥胖遗传标记作为肥胖的工具变量(iv);T2D的遗传标记由DIAGRAM Consortium鉴定为T2D的iv。COVID-19宿主遗传学计划使用MR- base平台对住院的COVID-19患者进行了MR分析。

结果：3类肥胖(1/2/3类)均为COVID-19住院的原因危险因素;但T2D作为独立因素并不会增加住院或危重型covid - 19的风险。

表1 COVID-19住院患者肥胖和2型糖尿病的MR分析

表2 COVID-19危重症患者肥胖和2型糖尿病的MR分析*

结论：肥胖是COVID-19住院的主要危险因素，而非T2D。

原文出处：Qu HQ, Qu J, Glessner J, Hakonarson H,Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patients.Metabolism 2022 Jan 28

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2022-06-28 一闲

#MET#

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2022-09-02 循证小兵

#肥胖#和#2型糖尿病#住院患者的#孟德尔随机化#研究

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2022-11-15 guojianrong

#Meta#

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2022-02-06 1249859em43(暂无昵称)

#Metabolism#

78 0
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2022-02-06 闆锋旦

#ABO#

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