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Ann Rheum Dis:炎性关节炎男性生育力受损

2021-08-10 MedSci原创 MedSci原创

这项研究表明IA会损害男性生育能力。在生育年龄高峰之前和期间被诊断为IA的男性生育率较低,无子女率较高,生育问题较多。

炎症性关节炎(IA)对男性生育能力的影响仍未明确。

近日,风湿病领域顶级期刊Annals of the Rheumatic Diseases上发表了一篇研究文章,研究人员旨在评估IA对男性生育结局的影响。

研究人员进行了一项多中心横断面研究。参与者完成了一份问卷,其中包括人口统计学、医学和生育相关问题。为分析IA对生育率的影响,根据诊断时的年龄将患者分组:≤30岁(育龄高峰前)、31-40岁(高峰期)和≥41岁(高峰后)。

该研究总共纳入了628名被诊断患有IA的参与者。IA诊断年龄≤30岁的男性平均子女数(1.32(SD为1.14))低于IA诊断年龄为31至40岁的男性(1.60(SD为1.35))和IA诊断年龄≥41岁的男性(1.88(SD为1.14)),且具有统计学显著性(p=0.0004)。IA诊断为30岁以下和31-40岁的男性非自愿无子女的百分比(12.03% vs. 10.34% vs. 3.98%,p=0.001)以及报告接受过生育问题医学评估的男性百分比(20.61%、20.69%和11.36%,p=0.027)在统计学上显著高于IA诊断为41岁以上的男性。

由此可见,这项研究表明IA会损害男性生育能力。在生育年龄高峰之前和期间被诊断为IA的男性生育率较低,无子女率较高,生育问题较多。

原始出处:

Luis Fernando Perez-Garcia,et al.Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility).Ann Rheum Dis.2021.https://ard.bmj.com/content/early/2021/08/02/annrheumdis-2021-220709

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1994576, encodeId=9fe519945e662, content=<a href='/topic/show?id=4286669e5ca' target=_blank style='color:#2F92EE;'>#炎性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66975, encryptionId=4286669e5ca, topicName=炎性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Oct 10 15:32:19 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948301, encodeId=db361948301bd, content=<a href='/topic/show?id=9dd5e025381' target=_blank style='color:#2F92EE;'>#男性生育力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70253, encryptionId=9dd5e025381, topicName=男性生育力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Wed Jun 08 18:32:19 CST 2022, time=2022-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013688, encodeId=01c52013688b5, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 06 04:32:19 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266297, encodeId=482f126629eba, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Aug 12 10:32:19 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390592, encodeId=95a8139059256, content=<a href='/topic/show?id=d14c695620d' target=_blank style='color:#2F92EE;'>#生育力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69562, encryptionId=d14c695620d, topicName=生育力)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Thu Aug 12 10:32:19 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006785, encodeId=56fd1006e8525, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210810/6ce3b236b9be400693c90d23bb389365/40a17e61634f490a940e13fb657551c5.jpg, createdBy=270e5568770, createdName=ms1000001397685178, createdTime=Tue Aug 10 22:32:05 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006742, encodeId=4aa31006e42ba, content=关注关节, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Tue Aug 10 21:34:36 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006725, encodeId=22a61006e259e, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08fd5569497, createdName=宫筱轩, createdTime=Tue Aug 10 20:02:34 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006719, encodeId=e4ed1006e195c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8f5451608, createdName=ms3000000426271603, createdTime=Tue Aug 10 19:38:16 CST 2021, time=2021-08-10, status=1, ipAttribution=)]
    2021-08-12 lmm397
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1994576, encodeId=9fe519945e662, content=<a href='/topic/show?id=4286669e5ca' target=_blank style='color:#2F92EE;'>#炎性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66975, encryptionId=4286669e5ca, topicName=炎性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Oct 10 15:32:19 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948301, encodeId=db361948301bd, content=<a href='/topic/show?id=9dd5e025381' target=_blank style='color:#2F92EE;'>#男性生育力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70253, encryptionId=9dd5e025381, topicName=男性生育力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Wed Jun 08 18:32:19 CST 2022, time=2022-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013688, encodeId=01c52013688b5, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 06 04:32:19 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266297, encodeId=482f126629eba, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Aug 12 10:32:19 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390592, encodeId=95a8139059256, content=<a href='/topic/show?id=d14c695620d' target=_blank style='color:#2F92EE;'>#生育力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69562, encryptionId=d14c695620d, topicName=生育力)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Thu Aug 12 10:32:19 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006785, encodeId=56fd1006e8525, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210810/6ce3b236b9be400693c90d23bb389365/40a17e61634f490a940e13fb657551c5.jpg, createdBy=270e5568770, createdName=ms1000001397685178, createdTime=Tue Aug 10 22:32:05 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006742, encodeId=4aa31006e42ba, content=关注关节, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Tue Aug 10 21:34:36 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006725, encodeId=22a61006e259e, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08fd5569497, createdName=宫筱轩, createdTime=Tue Aug 10 20:02:34 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006719, encodeId=e4ed1006e195c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8f5451608, createdName=ms3000000426271603, createdTime=Tue Aug 10 19:38:16 CST 2021, time=2021-08-10, status=1, ipAttribution=)]
    2021-08-10 ms1000001397685178

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1994576, encodeId=9fe519945e662, content=<a href='/topic/show?id=4286669e5ca' target=_blank style='color:#2F92EE;'>#炎性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66975, encryptionId=4286669e5ca, topicName=炎性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Oct 10 15:32:19 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948301, encodeId=db361948301bd, content=<a href='/topic/show?id=9dd5e025381' target=_blank style='color:#2F92EE;'>#男性生育力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70253, encryptionId=9dd5e025381, topicName=男性生育力)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Wed Jun 08 18:32:19 CST 2022, time=2022-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013688, encodeId=01c52013688b5, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Apr 06 04:32:19 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266297, encodeId=482f126629eba, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Aug 12 10:32:19 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390592, encodeId=95a8139059256, content=<a href='/topic/show?id=d14c695620d' target=_blank style='color:#2F92EE;'>#生育力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69562, encryptionId=d14c695620d, topicName=生育力)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqcyT7aQIuoYGGYr889lEiaOVWSfvMQ4d2oxhTMlWzEr6lPmg6pxzCVvPScSZrne4JFSyyPRCOxllQ/132, createdBy=416a2500064, createdName=ms3323097325231039, createdTime=Thu Aug 12 10:32:19 CST 2021, time=2021-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006785, encodeId=56fd1006e8525, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210810/6ce3b236b9be400693c90d23bb389365/40a17e61634f490a940e13fb657551c5.jpg, createdBy=270e5568770, createdName=ms1000001397685178, createdTime=Tue Aug 10 22:32:05 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006742, encodeId=4aa31006e42ba, content=关注关节, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Tue Aug 10 21:34:36 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006725, encodeId=22a61006e259e, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=08fd5569497, createdName=宫筱轩, createdTime=Tue Aug 10 20:02:34 CST 2021, time=2021-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1006719, encodeId=e4ed1006e195c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8f5451608, createdName=ms3000000426271603, createdTime=Tue Aug 10 19:38:16 CST 2021, time=2021-08-10, status=1, ipAttribution=)]
    2021-08-10 SR~young海东

    关注关节

    0

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    2021-08-10 宫筱轩

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    2021-08-10 ms3000000426271603

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