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Stroke:降压药对脑小血管病的影响!

2018-05-10 xing.T MedSci原创

由此可见,AHM对白质高信号的发展具有保护作用,但对脑萎缩没有影响。目前还没有关于AHM对腔隙、微出血、扩张血管周围间隙或急性小皮质下梗死影响的试验。

高血压是脑小血管疾病的一个重要危险因素。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估抗高血压药物(AHM)对脑小血管疾病进展的影响。

研究人员通过电子数据库系统地检索了2017年1月30日前发表的评估了AHM对1年后≥1脑小血管疾病磁共振成像标记(即白质高信号、腔隙、微出血、扩大的血管周围间隙、急性小皮质下梗死和脑萎缩)影响的文献。研究人员使用标准化均值差进行了随机效应荟萃分析。

研究人员共纳入了4项试验,包括卒中、糖尿病和≥70岁的患者。 AHM组患者在28至47个月内白质高信号进展较少(标准化平均差异为-0.19; 95%可信区间为-0.32至-0.06; I2=20%; n=1369)。两项试验报告了脑萎缩的进展和相互矛盾的结果。没有其他脑小血管疾病标志物的报道。

由此可见,AHM对白质高信号的发展具有保护作用,但对脑萎缩没有影响。目前还没有关于AHM对腔隙、微出血、扩张血管周围间隙或急性小皮质下梗死影响的试验。

原始出处:

Tessa van Middelaar,et al. Effect of Antihypertensive Medication on Cerebral Small Vessel Disease A Systematic Review and Meta-Analysis.Stroke. 2018.https://doi.org/10.1161/STROKEAHA.118.021160

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    2018-05-12 晴080

    嗯哼

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1644674, encodeId=a3fc16446e4ca, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Thu Mar 21 17:45:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715838, encodeId=019b1e15838b6, content=<a href='/topic/show?id=441b4e17253' target=_blank style='color:#2F92EE;'>#小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47172, encryptionId=441b4e17253, topicName=小血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=956e32082497, createdName=clmlylxy, createdTime=Sat Oct 20 17:45:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314487, encodeId=bf0c31448e1e, content=嗯哼, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIye4S46w30jWUTcbkVeCHMqwf2DIppcayvTGvXNWLQqF2pY4kPquBlOY5Xe1LgoGzdaVlyBYB1EQ/132, createdBy=d34a2345197, createdName=晴080, createdTime=Sat May 12 18:15:18 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291968, encodeId=85a91291968a8, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Sat May 12 00:45:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304258, encodeId=1c571304258ef, content=<a href='/topic/show?id=87068482845' target=_blank style='color:#2F92EE;'>#脑小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84828, encryptionId=87068482845, topicName=脑小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68f2317, createdName=天堂的云, createdTime=Sat May 12 00:45:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314012, encodeId=918a31401256, content=值得关注学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Fri May 11 06:46:42 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313843, encodeId=f8c431384305, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Thu May 10 16:01:49 CST 2018, time=2018-05-10, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1644674, encodeId=a3fc16446e4ca, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Thu Mar 21 17:45:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715838, encodeId=019b1e15838b6, content=<a href='/topic/show?id=441b4e17253' target=_blank style='color:#2F92EE;'>#小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47172, encryptionId=441b4e17253, topicName=小血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=956e32082497, createdName=clmlylxy, createdTime=Sat Oct 20 17:45:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314487, encodeId=bf0c31448e1e, content=嗯哼, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIye4S46w30jWUTcbkVeCHMqwf2DIppcayvTGvXNWLQqF2pY4kPquBlOY5Xe1LgoGzdaVlyBYB1EQ/132, createdBy=d34a2345197, createdName=晴080, createdTime=Sat May 12 18:15:18 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1291968, encodeId=85a91291968a8, content=<a href='/topic/show?id=9d32981418b' target=_blank style='color:#2F92EE;'>#降压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98141, encryptionId=9d32981418b, topicName=降压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Sat May 12 00:45:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304258, encodeId=1c571304258ef, content=<a href='/topic/show?id=87068482845' target=_blank style='color:#2F92EE;'>#脑小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84828, encryptionId=87068482845, topicName=脑小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68f2317, createdName=天堂的云, createdTime=Sat May 12 00:45:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314012, encodeId=918a31401256, content=值得关注学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Fri May 11 06:46:42 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313843, encodeId=f8c431384305, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Thu May 10 16:01:49 CST 2018, time=2018-05-10, status=1, ipAttribution=)]
    2018-05-11 baihao215

    值得关注学习

    0

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    2018-05-10 smartxiuxiu

    0

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