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Eur Respir J:职业性粉尘暴露与纵向肺功能下降无关 

2021-12-07 小文子 MedSci原创

近年来职业暴露于矿物粉尘、生物粉尘、气体与肺功能加速下降无关。

有研究证明,职业性空气暴露与肺功能下降和COPD有关。Eur Respir J杂志的一项研究探索了职业空气暴露与肺功能变化之间的关系。

研究数据来自两项一般人群的队列研究,哥本哈根城市心脏研究(CCHS)和哥本哈根一般人口研究(CGPS),平均随访9年(范围3-27年),至少进行两次肺功能测量。考虑以下主要类别的空气传播媒介:矿物粉尘、生物粉尘、气体和烟雾,以及复合气体、灰尘或烟雾。根据队列和时间段(1976-1983年和2003-2015年),使用线性混合效应模型研究每年平均职业暴露与FEV1平均年下降之间的相关性。随访期间校正了性别、身高、体重、教育程度、基线FEV1和每年吸烟包年。

研究共纳入16144人(平均年龄48岁,男性占43%),吸烟者比例分别为61%和20%。563人完成三次肺功能测量。暴露分析中,矿物粉尘、生物粉尘、气体和烟雾以及复合类别的职业暴露与FEV1下降无关。每天20支香烟与FEV1变化相关,FEV1变化为-17mL/年(95% CI, -19~ -15)。此外,基线FEV1和女性与FEV1的变化显著相关。暴露指数测量分析中,1976-1983年期间气体和烟雾与FEV1变化-5.8 mL/单位/年(95%CI, -10.8 ~ -2.3)相关,但在2001-2015年期间无关。

结果表明,来自丹麦普通人群的两个队列中,近年来职业暴露于矿物粉尘、生物粉尘、气体与肺功能加速下降无关,但可能在几十年前具有重要意义。

原文出处:

Stinna Skaaby, Esben Meulengracht Flachs, Peter Lange, et al, Occupational inhalant exposures and longitudinal lung function decline, European Respiratory Journal 2021 58: 2004341; DOI: 10.1183/13993003.04341-2020.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1941691, encodeId=98051941691d7, content=<a href='/topic/show?id=57eb8203240' target=_blank style='color:#2F92EE;'>#肺功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82032, encryptionId=57eb8203240, topicName=肺功能下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Jan 17 09:05:18 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1078045, encodeId=cae310e804527, content=职业暴露与copd的进展无关,这篇文章是得出这个结论吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27695151679, createdName=唐古拉山, createdTime=Wed Dec 08 10:48:55 CST 2021, time=2021-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077967, encodeId=4ae510e796745, content=在门诊接受治疗,但仍有部分患者重, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Wed Dec 08 07:18:07 CST 2021, time=2021-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077935, encodeId=f11a10e7935cb, content=必须重视职业病防治!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58001397990, createdName=yx1156, createdTime=Wed Dec 08 04:48:08 CST 2021, time=2021-12-08, status=1, ipAttribution=)]
    2021-12-08 唐古拉山

    职业暴露与copd的进展无关,这篇文章是得出这个结论吗

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1941691, encodeId=98051941691d7, content=<a href='/topic/show?id=57eb8203240' target=_blank style='color:#2F92EE;'>#肺功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82032, encryptionId=57eb8203240, topicName=肺功能下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Jan 17 09:05:18 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1078045, encodeId=cae310e804527, content=职业暴露与copd的进展无关,这篇文章是得出这个结论吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27695151679, createdName=唐古拉山, createdTime=Wed Dec 08 10:48:55 CST 2021, time=2021-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077967, encodeId=4ae510e796745, content=在门诊接受治疗,但仍有部分患者重, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Wed Dec 08 07:18:07 CST 2021, time=2021-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077935, encodeId=f11a10e7935cb, content=必须重视职业病防治!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58001397990, createdName=yx1156, createdTime=Wed Dec 08 04:48:08 CST 2021, time=2021-12-08, status=1, ipAttribution=)]
    2021-12-08 查查佳佳

    在门诊接受治疗,但仍有部分患者重

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1941691, encodeId=98051941691d7, content=<a href='/topic/show?id=57eb8203240' target=_blank style='color:#2F92EE;'>#肺功能下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82032, encryptionId=57eb8203240, topicName=肺功能下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Jan 17 09:05:18 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1078045, encodeId=cae310e804527, content=职业暴露与copd的进展无关,这篇文章是得出这个结论吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27695151679, createdName=唐古拉山, createdTime=Wed Dec 08 10:48:55 CST 2021, time=2021-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077967, encodeId=4ae510e796745, content=在门诊接受治疗,但仍有部分患者重, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Wed Dec 08 07:18:07 CST 2021, time=2021-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1077935, encodeId=f11a10e7935cb, content=必须重视职业病防治!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58001397990, createdName=yx1156, createdTime=Wed Dec 08 04:48:08 CST 2021, time=2021-12-08, status=1, ipAttribution=)]
    2021-12-08 yx1156

    必须重视职业病防治!!

    0

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