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Hypertension:围产期心肌病早期诊断的重要性

2019-11-11 xing.T MedSci原创

总之,这些结果强调了对早期监测和诊断的需求,特别是在高危人群和医疗服务水平低下的人群中。

围产期心肌病(PPCM)可能导致长期收缩功能障碍,尤其是在黑人女性中。妊娠高血压疾病(HDP)是PPCM的最强危险因素,但关于HDP是否预示良好结局仍存在争议。患有HDP的女性通常比没有HDP的女性更早被诊断出患有PPCM。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在根据HDP、诊断时机和种族分层来确定PPCM患者收缩功能是否恢复。研究人员对220名被诊断为PPCM的患者(55%为黑人)进行了回顾性队列研究。

PPCM和HDP的患者比没有HDP的患者在产后更早被诊断(P=0.013),这种现象在非黑人患者中最为明显。患有和没有HDP的PPCM患者的左心室射血分数(LVEF)恢复率相似(68.4% vs. 62.6%,P=0.425)。相比之下,产后1个月后诊断为PPCM的患者LVEF恢复率要低于产后1个月内被诊断的患者(53.7% vs. 69.9%,P=0.035)。诊断时的LVEF是LVEF恢复的强有力预测指标,与就诊较早的患者相比,产后1个月后诊断为PPCM的患者基线LVEF较低(P=0.041)。在该种族多样化的PPCM队列中,HDP的存在与LVEF的恢复无关。相反,早期诊断预示良好的结局。早期诊断与就诊时较高的左室射血分数有关,这可能解释了这些妇女预后的改善。

总之,这些结果强调了对早期监测和诊断的需求,特别是在高危人群和医疗服务水平低下的人群中。

原始出处:

Jennifer Lewey.et al.Importance of Early Diagnosis in Peripartum Cardiomyopathy.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13291

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    2020-09-02 feather89
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    2020-07-27 mgqwxj
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    2019-11-11 qingfengqishi5

    学习了,学习了

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