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Semin Arthritis Rheu:干燥综合征患者的痴呆风险

2018-07-05 xiangting MedSci原创

这项人群回顾性队列研究显示,SS患者罹患痴呆的风险升高。

自身免疫可能在早期痴呆中起作用。干燥综合征(SS)与痴呆之间的关联仍不清楚。这项研究旨在为这种关联提供流行病学证据。

这项为期12年台湾基于人群的回顾性队列研究分析了SS队列中的痴呆风险。研究人员还利用台湾卫生研究院维护的纵向健康保险数据库2000的数据,调查了SS患者中的痴呆发病率。为了平衡群组特征的发生率,研究人员使用倾向得分来匹配两个群组中的特定合并症。还通过使用Cox比例风险模型分析了具有不同潜在风险患者中SS与痴呆的关联。

根据对2000-2012年间随访数据的分析,SS队列中痴呆的发病率为对照组的1.21倍(95%置信区间[CI] = 1.02-1.45,p<0.05)。在65岁以上组中,痴呆的发病率显著升高(校正风险比[aHR] = 5.30,95%CI=4.26-6.60,p<0.01)。调整包括帕金森病(aHR=2.98,95%C =1.80-4.94)、失眠(aHR=1.45,95%CI=1.14-1.85)和高血压(aHR=1.43,95%CI=1.19- 1.71)在内的合并症后,SS和痴呆之间的关联仍然显著。

这项人群回顾性队列研究显示,SS患者罹患痴呆的风险升高。

原始出处:

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    2018-08-01 lixon1988

    自身免疫可能在早期痴呆中起作用。

    0

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    2018-07-07 zhaojie88
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