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Sci Rep:难治性膀胱疼痛综合征/间质性膀胱炎的骶神经调节

2017-09-19 AlexYang MedSci原创

膀胱疼痛综合征/间质性膀胱炎(BPS/IC)是一种常见的衰竭性疾病,并且到目前为止还没有持续有效的治疗方法。最近,有研究人员评估了难治性BPS/IC的骶神经调节(SNM)的所有可利用的文献资料。研究人员对Pubmed、Web of Science和Cochrane Library数据库的到2016年5月的数据进行了综合性的搜索。最后,鉴定出了17个研究,并包含了583名病人。研究发现,合并分析表明

膀胱疼痛综合征/间质性膀胱炎(BPS/IC)是一种常见的衰竭性疾病,并且到目前为止还没有持续有效的治疗方法。最近,有研究人员评估了难治性BPS/IC的骶神经调节(SNM)的所有可利用的文献资料。研究人员对Pubmed、Web of Science和Cochrane Library数据库的到2016年5月的数据进行了综合性的搜索。最后,鉴定出了17个研究,并包含了583名病人。

研究发现,合并分析表明SNM与骨盆痛的大量减少(加权均数差WMD,-3.99;95%置信区间CI,-5.22到-2.76;p<0.00001)、间质性膀胱炎问题和症状指数得分(分别为WMD 6.34; 95% CI 9.57 to 3.10; p=0.0001和 WMD 7.17; 95% CI 9.90 to 4.45; p<0.00001)、白天频率(WMD 7.45; 95% CI 9.68 to 5.22; p<0.00001)、遗尿症(WMD 3.01; 95% CI 3.56 to 2.45; p<0.00001)、每24小时排尿次数(WMD 9.32; 95% CI 10.90 to 7.74; p<0.00001)和尿急(WMD 1.08; 95% CI 1.79 to 0.37; p=0.003)以及平均排尿体积的显著提高(WMD 95.16ml; 95% CI 63.64 to 126.69; p<0.0001)相关。另外,联合治疗的成功率为84%(95% CI 76% to 91%),SNM相关的不良事件是最低的。最后,研究人员指出,目前的证据表明了SNM也许治疗难治性BPS/IC的有效的和安全的方法。

原始出处:


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    2017-09-21 freve
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