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JCEM:年轻人对短期寒冷暴露的反应存在性别差异

2020-03-10 MedSci原创 MedSci原创

由此可见,研究人员没有观察到男性和女性对CE的产热反应的差异(以REE的变化来衡量)。但是,研究人员发现与男性相比,女性的某些代谢指标和激素变化更为明显,这表明对寒冷的反应存在性别特异性。

已有研究表明寒冷暴露(CE)通过激活人类棕色脂肪组织的生热和代谢作用来增加能量消耗。但是,寒冷诱导的产热和代谢是否存在性别特异性差异尚待阐明。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在明确轻度CE对男性与女性对静息能量消耗(REE)和代谢的影响。

该研究为横断面研究,117名健康的年轻白人参加了这项研究(58名男性)。平均年龄为25.1±3.6岁,平均BMI为22.3±1.7kg/m²。参加者使用灌水床垫进行短期CE干预,以激活非战栗产热效应。在CE之前和之后2小时评估REE,然后进行血液采样。研究人员测量了样本中选定的代谢物和激素。在整个实验过程中,监测了各个部位的皮肤温度。

参与者在接受CE后的REE显著增加(6.5%,p<0.001),男性与女性之间的增加程度没有差异(p=0.908)。但是,在CE后男性和女性血浆葡萄糖(-5.1% vs. -7.4%,p=0.024)、瘦素(-14.3% vs. -30.1%,p<0.001)和脂联素(5.4% vs. 12.8%,p=0.018)水平存在差异。研究人员观察到男性锁骨上皮肤温度显著降低(-0.3%,p=0.034),而女性没有(0.3%,p=0.326)(性别间p=0.019)。

由此可见,研究人员没有观察到男性和女性对CE的产热反应的差异(以REE的变化来衡量)。但是,研究人员发现与男性相比,女性的某些代谢指标和激素变化更为明显,这表明对寒冷的反应存在性别特异性。

原始出处:

Laura A Mengel,et al.Gender differences in the response to short-term cold exposure in young adults.J Clin Endocrinol Metab.2020.https://doi.org/10.1210/clinem/dgaa110

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    2021-02-14 smallant2015
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    2020-04-28 achengzhao
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    2020-03-11 huagfeg
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    2020-03-09 天地飞扬

    学习了

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