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J Intern Med:酒精摄入、吸烟与主动脉瓣狭窄发病率

2017-10-25 佚名 环球医学

主动脉瓣狭窄(AVS)是最常见的瓣膜性心脏病,在65岁以上的人群中发病率为2~7%。 AVS是一种进行性疾病,其终末期与心血管原因的高发病率和死亡率相关。未经治疗的严重AVS患者,2年死亡率近50%。2017年10月,发表在《J Intern Med》的一项由瑞典科学家进行的研究,考察了饮酒、吸烟与AVS风险的相关性。

主动脉瓣狭窄(AVS)是最常见的瓣膜性心脏病,在65岁以上的人群中发病率为2~7%。 AVS是一种进行性疾病,其终末期与心血管原因的高发病率和死亡率相关。未经治疗的严重AVS患者,2年死亡率近50%。2017年10月,发表在《J Intern Med》的一项由瑞典科学家进行的研究,考察了饮酒、吸烟与AVS风险的相关性。

题目:酒精摄入、吸烟与主动脉瓣狭窄发病率

背景:酒精摄入和吸烟是对公众健康有重要影响的可改变的生活方式。目前仍不清楚这些因素是否会影响主动脉瓣狭窄(AVS)风险。

目的:在2个前瞻性队列中,考察酒精摄入和吸烟(包括吸烟强度和戒烟时间)与AVS发病率的相关性。

方法:本分析是基于瑞典乳房X光检查队列和瑞典男性队列的数据,包括69365名基线时无心血管疾病的成年人。通过链接至瑞典全国患者和死亡原因注册库,对受试者的AVS发病率和死亡进行随访。采用Cox比例风险回归估算风险比(HR)和95%置信区间(CI)。

结果:在平均随访期15.3年后,1249例AVS(女性有494例,男性有755例)被记录。与从不喝酒的人(终身戒酒者)相比,目前少量饮酒者的AVS风险明显降低(每周1-6次[1次=12 g酒精];多变量HR 0.82;95%CI:0.68~0.99)。AVS风险随着吸烟强度的增加而增加。同从未吸烟者相比,目前吸烟≥30 包-年的吸烟者HR是1.46(95%CI:1.16~1.85)。戒烟10年或以上的先前吸烟者与从未吸烟者具有相似的AVS风险。

结论:本研究证实目前少量饮酒与较低的AVS风险相关,并指出吸烟和AVS风险的相关性是可逆的。

原始出处:

Larsson SC, Wolk A, Back M.Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis.J Intern Med. 2017 Oct;282(4):332-339.

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相关资讯

J INTERN MED:饮酒、吸烟与主动脉瓣狭窄的发生率有何关系?

这项研究表明目前的轻度酒精摄入与较低的AVS风险相关,并表明吸烟和AVS风险之间的相关性是可逆的。

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